Archive for September, 2008

Immune system both shields as well as promotes tumour growth

Tuesday, September 30th, 2008

In a new study, researchers at the University of Pennsylvania School of Medicine have discovered that some proteins of the immune system can promote tumor growth.According to John D. Lambris, PhD, the protein C5a, which is produced during an immune response to a developing tumour, helps tumours build molecular shields against T-cell attack.

C5a belongs to the complement system, one of the body’s immune defenses against pathogens. If the system proteins get activated they can relieve the body of microbes and foreign cells.

In fact, a large number of cancer treatments are aimed at boosting the immune system to kill tumours.

“Until now, everyone thought that the complement system was there to eliminate tumor cells. We found that in some conditions, the complement system can promote tumor growth, depending on the specific tumor and the specific environment in which the tumors are developing,” Nature quoted Lambris as saying

But, the scientists discovered that in a mouse model, activation of the complement system in tumour tissue leads to the generation of C5a.

C5a then ropes in myeloid-derived suppressor cells (MDSC) to tumours. The MDSCs block the function of CD8+ T cells, which would normally dismantle a tumour.

The scientists also found that blocking the C5a receptor on cell surfaces impairs tumour growth at the same rate of Paclitaxel, a chemotherapy drug.

The discovery could lead to new cancer treatments with far fewer side effects than chemotherapy.

“Researchers are trying to introduce immune therapies and anti-tumor vaccines, but most of these vaccines fail. We show in this study a possible mechanism how to overcome this problem,” said Lambris.

The researchers are conducting studies that utilise the approaches described in this paper to five models of cancer.

The findings appeared online in Nature Immunology.

Oil falls to near $103 on global slowdown fears

Tuesday, September 30th, 2008

Oil prices on Monday fell to near USD 103 a barrel in Asia on concern that economic growth will slow across the globe despite a tentative agreement in Washington on a USD 700 billion bailout package to stabilize the US financial system.

Light, sweet crude for November delivery was down USD 3.73 to USD 103.16 a barrel in electronic trading on the New York Mercantile Exchange by mid-afternoon in Singapore. The contract fell Friday USD 1.13 to settle at USD 106.89.

Congressional leaders and the White House yesterday agreed to a rescue of the ailing financial industry after lawmakers insisted on sharing spending controls with the Bush administration. The biggest US bailout in history won the tentative support of both presidential candidates and goes to the House of Representatives for a vote today.

“The bailout package reduces the chance of a complete meltdown,” said Victor Shum, an energy analyst with Purvin & Gertz in Singapore. “But worries on the demand side will continue to weigh on oil prices.”

The plan would give the administration broad power to use hundreds of billions of taxpayer dollars to purchase devalued mortgage-related assets held by cash-starved financial firms.

Congress insisted on a stronger hand in controlling the money than the White House had wanted. The government would take over huge amounts of devalued assets from beleaguered financial companies in hopes of unlocking frozen credit.

“It’s still a crisis situation,” Shum said. “The market is concerned about the depth and breadth of this global downturn.”

Prices were also pushed down by a stronger dollar.

Analysts: Mobile to weather world financial storm

Tuesday, September 30th, 2008

The mobile-phone industry is expected to boom, despite the current global financial crisis, thanks to new growth in emerging markets, according to Portio Research.

In a Monday report, the analyst firm predicted that the world’s population of mobile-phone users will increase from the current 50 percent to 80 percent in 2013. This translates to a “staggering 5.8 billion people,” Portio said.

“The mobile industry continues to confound expectations with spectacular accelerating growth,” the report stated, attributing the growth mainly to China and India’s markets.

China topped Portio’s list of top growth markets, followed by India. With the two countries expected to jointly contribute some 1 billion additional mobile subscribers between 2007 and 2013, Brazil is a “distant third,” with 132 million additional subscribers expected, the research firm said.

Portio’s report echoed similar findings from another recent report from the International Telecommunication Union.

The industry body predicted that global mobile subscribers will reach 4 billion by the end of this year, fueled by the BRIC (Brazil, Russia, India, China) countries. But, the ITU noted that this figure does not factor in double counting, in which one user has multiple subscriptions, and pegged the overall global mobile penetration rate at 61 percent by the end of 2008.

Revenue margins will dip However, the Portio report projected that the average revenue per user will continue to decline from $23.20 in 2005 to $15.80 by the end of 2013. The falling margins are due to additional subscribers from low per-capita income markets.

The report also singled out Nokia as the market share leader, having shipped 437 million handsets last year. The Finnish handset maker’s success has been linked to its performance in developing markets, in relation to competitors’ sales figures in these regions, according to Portio.

Nokia appears to be continuing its focus on the lucrative emerging markets. It recently launched a global Symbian app competition calling for developers to “think about the needs of (emerging) markets,” with hopes of making handsets that are more attractive to users in these markets.

Victoria Ho of ZDNet Asia reported from Singapore.

Britney Spears says she plans to tour again

Tuesday, September 30th, 2008

Britney Spears said she plans to make her first international tour since 2004 to support her new album, “Circus.”In an interview broadcast on Monday by New York radio station Z100, Spears was asked if she planned to tour.

“Oh definitely, next year,” she said, adding the tour would probably take her “around the world.”

That would mark her first major concert tour since 2004.

Last year, Spears performed in a handful of club shows in southern California under the name the M+M’s but did not go on the road to promote her last album, “Blackout,” which had a good chart debut in November 2007 but faded quickly.

After more than a year of making headlines for shaving her head, attacking paparazzi with an umbrella and two admissions to psychiatric hospital units, Spears, 26, is preparing for a comeback.

Her last live public performance was a much-ridiculed rendition of “Gimme More” at the MTV Video Music Awards a year ago.

The singer’s latest single, “Womanizer,” was released on Friday and is the first single off “Circus,” which will be released on Dec. 2 — her 27th birthday. She told Z100 she spent six months working on the album.

Spears has been on the mend since her father took control of her business affairs in February. She won three awards for her song “Piece of Me” at this year’s MTV video music awards.

Before her life spiraled out of control, Spears was an international pop phenomenon and one of the best-selling artists of the last decade with sales of more than 62 million albums.

Saif Ali Khan in assault trouble in Punjab

Tuesday, September 30th, 2008

Bollywood star Saif Ali Khan found himself in trouble Monday after the Government Railway Police (GRP) registered a case against him and four others of a film unit for allegedly assaulting a photojournalist.Khan and members of the unit of his latest film ‘Three Idiots’ were booked for assault, intimidation and inciting violence.

GRP officials said the move followed a complaint by a photojournalist from a Hindi newspaper who said he had been beaten up by the film unit staff after being incited by Khan.

The photographer was taking pictures of Khan at the railway station here Sunday. The star objected and told private security and film production unit associates to tackle the photojournalist following which he was allegedly thrashed.

‘We will arrest him soon,’ GRP inspector general G.J.S. Grewal said here.

The registration of the case follows protests by mediapersons against Khan and others.

Game Club Cafe Mac game portal launches

Monday, September 29th, 2008

Codeminion has announced the launch of Mac games in Game Club Cafe, its casual game portal.

The portal launches with more than 50 casual Mac games, all from a variety of different game developers and publishers. Titles include Bejeweled 2, Azada, Atlantis Sky Patrol, Airport Mania: First Flight, Puzzle Quest and more.

Codeminion itself is an independent developer of casual games like Ancient Quest of Saqqarah, Stoneloops of Jurassica and Magic Match. Those games are also available for purchase and download.

The games are available on a try-before-you-buy basis, and are all priced at $19.95 each.

McCain defends Palin’s contradiction on Pakistan

Monday, September 29th, 2008

Republican presidential nominee John McCain defended running mate Sarah Palin on Sunday, even as she contradicted his policy against talking publicly about attacking terrorist targets in Pakistan.

McCain chided Democrat Barack Obama during Friday’s presidential debate for saying publicly he supports striking terrorist targets inside Pakistan if the Pakistani government is unable or unwilling to do so.

Osama bin Laden and other top al-Qaida leaders are thought to be hiding in tribal areas along the Pakistan-Afghanistan border. Obama has said he would support sending American troops into Pakistan to attack such high-value targets.

“You don’t say that out loud,” McCain said during the debate. “If you have to do things, you do things.”

But on Saturday, Palin said much the same thing to a customer at a Philadelphia restaurant, with the press nearby.

“If that’s what we have to do stop the terrorists from coming any further in, absolutely, we should,” Palin said in the exchange, which was captured on video and reported by CBS News.

Palin, the governor of Alaska, energized McCain’s campaign when he chose her as a running mate just before the Republican convention. But polls show Palin’s popularity waning among some as she has struggled to answer questions about foreign policy in the few interviews she has granted to journalists.

“She was in a conversation with some young man,” McCain said during his own interview Sunday on ABC’s “This Week.” “She understands and has stated repeatedly that we’re not going to do anything except in America’s national security interest and we are not going to, quote, announce it ahead of time.”

McCain said Palin’s exchange was not an official policy statement.

“I don’t think most Americans think that that’s a definitive policy statement made by Governor Palin,” McCain said.

Pictorial warnings on cigarette packs in Britain

Monday, September 29th, 2008

Pictures showing gruesome effects of smoking on the body will replace text warnings on cigarette packets in Britain from Oct 1.The images - which include pictures of rotting teeth and lungs, throat cancer, and a ‘flaccid’ cigarette - will replace the written warnings featured on packs, introduced in January 2003.

Britain is the first country in the European Union (EU) to introduce pictorial warnings. The government is considering going even further and legislating that all packaging must be plain white, with only the brand name and the warnings.

Chief Medical Officer Sir Liam Donaldson told The Telegraph: ‘I welcome the introduction of picture warnings on tobacco product packaging, which show smokers the grim reality of the effects smoking can have on their health. This will help to maintain the momentum of the increasing number of people who have given up smoking following England going smoke free in 2007.’

Stephen Singleton, regional director of public health, said: ‘The introduction of picture warnings on to tobacco product packaging provides a very stark warning to smokers.’

Smoking is the biggest preventable cause of death in Britain, causing the premature death of more than 87,000 people each year.

There are 10 million smokers in Britain and around half of them will die early as a result of their habit, according to health department studies.

Following the ban on smoking in public places and bars and restaurants and a campaign by the NHS, more than 350,000 smokers stopped smoking with local NHS Stop Smoking Services around the country.

Jennifer Hudson had to dig out engagement ring

Monday, September 29th, 2008

Singer-actress Jennifer Hudson got the ‘biggest surprise’ of her life recently when boyfriend David Otunga asked her to be his wife at a beach on her 27th birthday. He gave her a shovel to dig out the engagement ring.They got engaged on Sep 12.

Contactmusic.com reports her as saying: ‘It was a big deal. I got a beautiful ring and I got him. I had no clue at all. We went to the beach during the day and he blindfolded me and he gave me a purple shovel, because purple’s my favourite colour… and I had to dig. I ended up digging through all this sand.

‘When I found it, it was like a bunch of beautiful cards - one related to the other, and the last one said, ‘Look around, take the moment in, turn around and I have a gift for you’.’

Hudson showed off the ring on a TV show recently and called her to be husband ‘a beautiful guy’ and boasted, ‘He’s an attorney, he went to Harvard Law School.’

Chinese astronaut takes historic walk in space

Sunday, September 28th, 2008

Astronaut Zhai Zhigang became the first Chinese man to walk in space on Saturday, clambering out of China’s Shenzhou VII spacecraft in a technological feat that Beijing wants the world to marvel at.

“I’m feeling quite well. I greet the Chinese people and the people of the world,” Zhai said as he climbed out of the craft, his historic achievement carried live on state television.

Zhai, the 41-year-old son of a snack-seller, unveiled a small Chinese flag, helped by colleague Liu Boming, who also briefly popped his head out of the capsule.

Zhai re-entered the spacecraft safely after a walk of about 15 minutes, marking the high point of China’s third manned space flight, which has received blanket media coverage.

He wore a $4.4 million Chinese-made suit weighing 120 kg (265lb). Liu wore a Russian-made suit and acted as a back-up.

Zhai, tethered to the ship, slowly made his way toward a chunk of solid lubricant outside the capsule, took a sample and handed it to Liu, the official Xinhua news agency said, in an experiment aimed at improving the durability of the materials.

The crew later launched a small satellite to take the first full images of the spacecraft from the outside.

Shenzhou VII, which took off on Thursday, is due to land on Sunday at around 5 p.m (0900 GMT), said mission spokesman Wang Zhaoyao.

President Hu Jintao spoke to the astronauts on their return to the capsule, congratulating them on their efforts and wishing them a “triumphant” return.

“You’ve done a great job,” Hu said.

Zhai, apparently reading from a prepared script, thanked Hu. “The space walk mission has been accomplished smoothly. Please set your mind at ease, Chairman Hu and the people of China,” Zhai said.

“In the vastness of space, I felt proud of our motherland.”

The risky space walk was a step toward China’s longer-term goal of assembling a space lab and then a larger space station.

The fast-growing Asian power wants to be sure of a say in the future use of space and its resources.

Chinese Communist Party leaders, also celebrating the mission, hailing the country’s achievements in a year in which Beijing has staged a successful Olympics and coped with a devastating earthquake in Sichuan in May.

“UPBEAT NOTE”

A Xinhua commentary praised the mission as adding “an upbeat note to an eventful year” — references to events such as the earthquake.

“(The space mission) is seen as another source of pride and joy for the people after the Olympics.”

But Xinhua also said that China remained far behind the two leading space powers, Russia and the United States. “Compared with these countries, China is still a latecomer and is only taking its starting steps,” it said.

Xinhua said millions tuned in to watch the event on television, some on large outdoor screens.

“It’s worth the money. It shows our country is getting stronger, and other countries will not dare bully us,” said civil servant Jiang Guishan, watching along with hundreds of others in Beijing’s fashionable Wangfujing shopping district.

“We have encountered a lot of difficulties, but we will not be defeated when faced with them, and will only overcome the obstacles and be strong. Now this is a great example,” added travel agent Wu Qixin.

China’s space programme has come a long way since late leader Mao Zedong, founder of Communist China in 1949, lamented that the country could not even launch a potato into space.

China’s first manned spaceflight was in 2003, followed by a two-man flight in 2005. The only other countries that have sent people into space are Russia and the United States.